GLP-1 Titration Planner

Build your personalized dose escalation calendar. FDA-based week-by-week schedules for Ozempic, Wegovy, Mounjaro & Zepbound.

Your Plan

First injection: Friday, Feb 27, 2026

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Drag to simulate your progress through titration

Titration Progress
1of 5 steps
Start0% completeTarget Dose

Current Dose

0.25 mg

Next Escalation

28 days

Mar 27, 2026

Week

1-4

0.25 mgStartingCurrent

Feb 27 – Mar 26, 2026•Week 1

1
2
0.5 mg

Mar 27 – Apr 23, 2026•Week 5

2
3
1 mg

Apr 24 – May 21, 2026•Week 9

3
4
1.7 mg

May 22 – Jun 18, 2026•Week 13

4
5
2.4 mgTarget

Jun 19 – Jul 16, 2026•Week 17

5

Total Duration

20

weeks to target

Escalations

4

dose increases

Generic Name

semaglutide

active ingredient

Maintenance

2.4 mg

target dose

FDA-Approved Titration Protocol

This schedule follows the exact titration protocol approved by the FDA based on the Wegovy Prescribing Information (Novo Nordisk, 2024). Each dose is administered once weekly for exactly 4 weeks before escalating. This gradual approach minimizes gastrointestinal side effects while allowing your body to adapt to the medication.

Source: Ozempic PI · Wegovy PI · Mounjaro/Zepbound PI

FDA-Approved ScheduleWegovy

When to Contact Your Doctor

  • • Severe or persistent vomiting lasting more than 24 hours
  • • Signs of dehydration (dark urine, dizziness, rapid heartbeat)
  • • Severe abdominal pain or suspected pancreatitis
  • • Allergic reactions (rash, itching, difficulty breathing)
  • • If side effects prevent you from maintaining the scheduled dose

Why Titration Matters

GLP-1 medications require a gradual dose escalation called titration. This isn't just a suggestion—it's clinically necessary to allow your body to adapt to the medication and minimize gastrointestinal side effects like nausea, vomiting, and diarrhea.

The Science Behind the Schedule

The FDA-approved titration schedules are based on the landmark STEP (semaglutide) and SURMOUNT (tirzepatide) clinical trials. These studies demonstrated that patients who follow the prescribed escalation timeline experience significantly fewer side effects while achieving optimal weight loss outcomes.

Each dose level is maintained for exactly 4 weeks before escalating. This allows the medication to reach steady-state concentrations in your body and gives your gastrointestinal system time to adapt to the slowed gastric emptying that GLP-1 medications cause.

Medication-Specific Schedules

  • Ozempic (semaglutide): 4-step escalation over 16 weeks—0.25mg → 0.5mg → 1mg → 2mg. The 2mg dose (Ozempic 2.0) is the maximum approved for type 2 diabetes.
  • Wegovy (semaglutide): 5-step escalation over 20 weeks—0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg. The 2.4mg dose is the therapeutic target for chronic weight management.
  • Mounjaro/Zepbound (tirzepatide): 6-step escalation over 24 weeks—2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg. Tirzepatide has a longer titration path due to its dual GIP/GLP-1 mechanism.

What Happens During Each Phase

Weeks 1-4 (Starting Dose): This is an acclimation period. The dose is sub-therapeutic, meaning it's designed to introduce your body to the medication, not to produce significant weight loss. Side effects are typically mildest during this phase.

Weeks 5-8 (First Escalation): Most patients begin noticing appetite suppression. Nausea may peak during week 5-6 as your body adjusts to the higher dose. Eating smaller, more frequent meals helps.

Weeks 9-16 (Mid-Titration): Weight loss typically accelerates. By week 12, many patients have lost 5-8% of their starting weight. Side effects usually diminish as the body adapts.

Weeks 17+ (Therapeutic Dose): You've reached the target maintenance dose. This is where maximum efficacy is achieved—clinical trials show average weight loss of 15-22% depending on medication.

5 Tips for Successful Titration

1. Stay at each dose for exactly 4 weeksEven if you're feeling great, rushing the titration increases side effect risk. Conversely, extending beyond 4 weeks without medical reason may delay your therapeutic benefits.
2. Plan for injection day side effectsNausea often peaks 24-48 hours after your injection. Schedule your injections on days when you can take it easier if needed—many patients prefer Friday evenings.
3. Eat slower and smallerAs doses increase, gastric emptying slows. Meals that used to be comfortable may now cause fullness or nausea. Reduce portion sizes and eat more slowly starting at week 5.
4. Hydrate aggressively during escalationsWater intake needs increase during dose escalations. Aim for an extra 16oz (0.5L) daily in the week following each dose increase to combat constipation and nausea.
5. Track your symptomsUse a tracking app to log side effects, weight, and how you feel at each dose. This data becomes invaluable if you need to discuss adjustments with your doctor.

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Frequently Asked Questions

This estimator uses data from the FDA-approved clinical trials (STEP 1 for Wegovy/Ozempic and SURMOUNT-1 for Zepbound/Mounjaro). It projects the "average" weight loss curve. However, individual results vary significantly based on genetics, lifestyle, dosage adherence, and starting BMI. Some users are "super-responders" losing more, while others may lose less.
Different medications work on different receptors. Semaglutide (Wegovy, Ozempic) targets GLP-1 receptors, while Tirzepatide (Zepbound, Mounjaro) targets both GLP-1 and GIP receptors, which clinical trials suggest may lead to greater average weight loss.
Medication is a tool, not a cure. The most successful patients combine medication with a high-protein diet (to preserve muscle), resistance training, adequate sleep, and hydration. The estimator assumes these standard lifestyle interventions are being followed.

Disclaimer

Not Medical AdviceThis planner is for informational purposes only and does not constitute medical advice. Always follow the titration schedule prescribed by your healthcare provider, which may differ from standard protocols based on your individual circumstances.
Individual VariationSome patients may need slower titration due to side effects, while others may have medical reasons to maintain a lower dose long-term. Never escalate your dose without consulting your prescribing physician.
Missed DosesIf you miss a dose, follow the guidance in your medication's prescribing information or contact your healthcare provider. Do not double doses to "catch up" on your schedule.