GLP-1 Titration Planner

Map standard dose-escalation timelines so upcoming changes feel easier to anticipate. Based on common FDA-approved schedules.

Your Plan

First injection: Friday, Mar 27, 2026

12345

Drag to simulate your progress through titration

Titration Progress
1of 5 steps
Start0% completeTarget Dose

Current Dose

0.25 mg

Next Escalation

30 days

Apr 24, 2026

Week

1-4

0.25 mgStartingCurrent

Mar 27 – Apr 23, 2026•Week 1

1
2
0.5 mg

Apr 24 – May 21, 2026•Week 5

2
3
1 mg

May 22 – Jun 18, 2026•Week 9

3
4
1.7 mg

Jun 19 – Jul 16, 2026•Week 13

4
5
2.4 mgTarget

Jul 17 – Aug 13, 2026•Week 17

5

Total Duration

20

weeks to target

Escalations

4

dose increases

Generic Name

semaglutide

active ingredient

Maintenance

2.4 mg

target dose

FDA-Approved Titration Protocol

This schedule follows the exact titration protocol approved by the FDA based on the Wegovy Prescribing Information (Novo Nordisk, 2024). Each dose is administered once weekly for exactly 4 weeks before escalating. This gradual approach minimizes gastrointestinal side effects while allowing your body to adapt to the medication.

Source: Ozempic PI · Wegovy PI · Mounjaro/Zepbound PI

FDA-Approved ScheduleWegovy

When to Contact Your Doctor

  • • Severe or persistent vomiting lasting more than 24 hours
  • • Signs of dehydration (dark urine, dizziness, rapid heartbeat)
  • • Severe abdominal pain or suspected pancreatitis
  • • Allergic reactions (rash, itching, difficulty breathing)
  • • If side effects prevent you from maintaining the scheduled dose

Why Titration Matters

GLP-1 medications are usually started with a gradual dose escalation called titration. Following a standard schedule can help your body adapt more gradually and may make side effects easier to manage.

The Science Behind the Schedule

The FDA-approved titration schedules are informed by the landmark STEP (semaglutide) and SURMOUNT (tirzepatide) clinical trial programs. They offer a useful baseline for understanding how dose increases are commonly paced.

Standard schedules typically hold each dose for about 4 weeks before the next increase. In real life, clinicians sometimes slow that timeline down based on side effects, tolerability, supply, or patient preference.

Medication-Specific Schedules

  • Ozempic (semaglutide): 4-step escalation over 16 weeks—0.25mg → 0.5mg → 1mg → 2mg. The 2mg dose (Ozempic 2.0) is the maximum approved for type 2 diabetes.
  • Wegovy (semaglutide): 5-step escalation over 20 weeks—0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg. The 2.4mg dose is the therapeutic target for chronic weight management.
  • Mounjaro/Zepbound (tirzepatide): 6-step escalation over 24 weeks—2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg. Tirzepatide has a longer titration path due to its dual GIP/GLP-1 mechanism.

What Happens During Each Phase

Weeks 1-4 (Starting Dose): This is an acclimation period. The dose is sub-therapeutic, meaning it's designed to introduce your body to the medication, not to produce significant weight loss. Side effects are typically mildest during this phase.

Weeks 5-8 (First Escalation): Most patients begin noticing appetite suppression. Nausea may peak during week 5-6 as your body adjusts to the higher dose. Eating smaller, more frequent meals helps.

Weeks 9-16 (Mid-Titration): Weight loss typically accelerates. By week 12, many patients have lost 5-8% of their starting weight. Side effects usually diminish as the body adapts.

Weeks 17+ (Therapeutic Dose): You've reached the target maintenance dose. This is where maximum efficacy is achieved—clinical trials show average weight loss of 15-22% depending on medication.

5 Tips for Successful Titration

1. Stay at each dose for exactly 4 weeksStandard schedules usually hold each dose for about 4 weeks. Your prescriber may keep you there longer if symptoms are harder than expected or if a slower pace simply makes more sense for you.
2. Plan for injection day side effectsSome people notice their hardest window 24-48 hours after an injection. It can help to choose a dose day that gives you more breathing room if that pattern shows up for you.
3. Eat slower and smallerAs doses increase, meals that used to feel easy may feel heavier or more filling. Smaller meals and a slower pace are common adjustments that many people experiment with.
4. Hydrate aggressively during escalationsSome people find it helpful to be more intentional about hydration during dose increases, especially if constipation or nausea tends to show up during that window.
5. Track your symptomsUse a tracking app to log side effects, weight, and how you feel at each dose. This data becomes invaluable if you need to discuss adjustments with your doctor.

Ready for a GLP-1 week that feels less random?

Use Dosio to notice the patterns behind side effects, appetite shifts, schedule changes, and progress.

Download on the App StoreGet it on Google Play

Frequently Asked Questions

This estimator uses data from the FDA-approved clinical trials (STEP 1 for Wegovy/Ozempic and SURMOUNT-1 for Zepbound/Mounjaro). It projects the "average" weight loss curve. However, individual results vary significantly based on genetics, lifestyle, dosage adherence, and starting BMI. Some users are "super-responders" losing more, while others may lose less.
Different medications work on different receptors. Semaglutide (Wegovy, Ozempic) targets GLP-1 receptors, while Tirzepatide (Zepbound, Mounjaro) targets both GLP-1 and GIP receptors, which clinical trials suggest may lead to greater average weight loss.
Medication is a tool, not a cure. The most successful patients combine medication with a high-protein diet (to preserve muscle), resistance training, adequate sleep, and hydration. The estimator assumes these standard lifestyle interventions are being followed.

Disclaimer

Not Medical AdviceThis planner is for informational purposes only and does not constitute medical advice. Always follow the titration schedule prescribed by your healthcare provider, which may differ from standard protocols based on your individual circumstances.
Individual VariationSome patients may need slower titration due to side effects, while others may have medical reasons to maintain a lower dose long-term. Never escalate your dose without consulting your prescribing physician.
Missed DosesIf you miss a dose, follow the guidance in your medication's prescribing information or contact your healthcare provider. Do not double doses to "catch up" on your schedule.