How are estimated medication levels calculated?

This app uses mathematical models to estimate medication concentration based on average data from peer-reviewed studies on how the body processes the active ingredients in GLP-1 medications.

Medication Half-Lives

The active ingredient in your medication determines how long it stays in your body. We use the following half-life values based on FDA prescribing information:

• Ozempic®, Wegovy®, Retatrutide®

  • Active Ingredient: Semaglutide/Other
  • Half-Life: ~7 Days (168 hours)

• Mounjaro®, Zepbound®

  • Active Ingredient: Tirzepatide
  • Half-Life: ~5 Days (120 hours)

While this provides a general idea of typical drug behavior over time, it is not a measurement, and is not specific to individual health profiles. For any medication-related decisions, please consult with a healthcare professional.

What does the graph show?

When you take a shot, a large amount of medication enters your system at once, causing the line on the chart to spike up. Over the following days, your body slowly processes the medication, causing the line to curve downward until your next dose.

Sources

• MOUNJARO (tirzepatide) injection, for subcutaneous use May 2022 - US Food and Drug Administration
• OZEMPIC (semaglutide) injection, for subcutaneous use Dec 2017 - US Food and Drug Administration
• WEGOVY (semaglutide) injection, for subcutaneous use Jun 2021 - US Food and Drug Administration
• ZEPBOUND (tirzepatide) injection, for subcutaneous use Nov 2023 - US Food and Drug Administration